The Nuri Cu-W-Mo deposit, located in the east-south gandise belt, is a large skarn deposit associated with the biotite granite, in the Northern yarlung zangbo suture zone. Zircon U-Pb dating and trace element of the biotite granite were studied to understand relationship with scheelite in north ore, based on the LA-ICP-MS U-Pb geochronological investigation of 18 zircon grains in biotite granite. The results shows that the growth zonal apparently ,and Th/U ratio range between 0.1~1.23(except 18 point) more than 0.1, is the typical magmatic zircon. The U-Pb ages of zircon can be divided into three groups: 799Ma, 55.6 Ma and 45.6~52.7 Ma, representing the formation time of Lhasa block at neoproterozoic, the captured zircons age, the formation age of biotite granite. The U-Y、Nb/Ta-Y discrimination diagram of zircon trace element indicates that all of the points fall in granitoid rock range, indicating that the biotite granite derived from the Lhasa block. The dating data show that they formed during the Eocence epoch. This age is exactly the middle-late time at the main collision of the India-Eurasia, corresponding to the India plate subduction to Eurasia plate collision middle-late stage magma event, and the age is earlier than molybdenite formation age but same as the first stage of Re-Os age of chalcopyrite. The two phases in the metallogenic events are early stage such as scheelite and chalcopyrite mineralization and late stage such as molybdenite and chalcopyrite. This is the first study in the southern margin of the metallogenic belt, its enriched the magmatic intrusion sequence and metallogenic events and have a great theoretical guidance significance for regional prospecting.