Four NNE-striking major normal faults were developed along the Jiangsu segment of the Tan-Lu Fault Zone during extensional activities of Cretaceous. They are abbreviated by F1, F2, F3 and F4 faults from east to west. The normal faults controlled development of the NNE-trending eastern graben、western graben and a horst between the two grabens. The F5 fault occurs in the eastern graben. Detailed field investigation shows that active faults widely appear in the Jiangsu segment of the Tan-Lu Fault Zone. The F2, F3 and F5 active faults mainly show thrusting while the northern segment of the F1 fault presents reverse dextral slip. Computation of fault-slip data suggests that activity of the active faults results from ENE-WSW compression which is consistent with present stress filed in this region. Comprehensive analyses demonstrate that the latest active time for the F1, F2, F3 and F5 faults is late Pleistocene, and that the northern part of the F4 fault shows activity since Quaternary whereas the southern part exhibits no Quaternary activity. Fault displacement data and Quaternary deposition suggest that the F2 and F5 faults show more strong activity. Comprehensive analyses suggest that the active faults in the Jiangsu segment are derived mostly from direct reactivity of previous normal fault, and present the characteristics of inhomogeneous and discontinuous activities. The F5 active fault with a longer extension in the Shandong segment extends into the Jiangsu segment, and shows the formation mechanism of previous normal fault reactivity.