The Mesozoic shoshonotic series volcanic rocks in the Lower Yangtze River reaches restricted in the Ningwu, Luzong, Lishui and Huaining four basins. The series are characterized by high-K and alkali enrichment. In geochemistry, these rocks enriched in strong incompatible elements such as Rb, Th, U and K as well as light rare earth elements (LREE), depleted in high-field-strong-elements (HFSE) such as Nb and Ta. The Sr and Ba characteristics of the rocks vary with lithology, indicating that the fractional crystallization of plagioclase may play an important role during magma evolution in these basins. Some geochemistry characteristics(such as Ce/Yb) of the shoshonotic series volcanic rocks in the basins are similarly with that of intra-oceanic island arcs, possibly because the lithospheric thinning allowed the asthenospheric mantle upwelled to relatively shallow depth where a greater proportion of spinel-facies melting can contribute to magma generation. The Nd and Sr isotope compositions of the rocks are roughly similar with the enriched subcontinental lithospheric mantle of the Yangtze craton, imply that their parental magma were mainly come from partial melting of the enriched subcontinental lithospheric mantle. But the tectonic setting of the basins are also play an obvious role on the magma characteristics, indicating the existing of crustal contamination. The whole shoshonotic series volcanic rocks in the Lower Yangtze region formed in a very short period from 128 to 134 Ma, with a peak about 130 Ma. The genesis of the shoshonotic magma may be related with the lithospheric thinning of the eastern China in the late Mesozoic.