The tectonic subsidence history of the Ganluo were reconstructed by using apatite fission-track, Zircon fission-track and vitrinite reflectance data of clastic rock, and correlative restriction on preservation of Zn-Pb Deposit in Ganluo was discussed. Three stages could be compartmentalized as follows: (1) During Late Triassic epoch, influenced by the subduction of the East Tethys Ocean basin, the tectonic environment of Ganluo area changed into paraforeland basin, and the buried depth stara increased rapidly, with the incremental quantity more than 7.6km. (2) Early Jurassic-Paleogene, at this stage, the tectonic regime of Ganluo area transformed and the stara uplifted discontinuously and slowly, the average uplift rate is no more than 32.7m/Ma; (3) Since the beginning of Neogene epoch, the stara of Ganluo uplift quickly, the uplift amplitude in the Northern of Ganluo is more than the Southern, the average uplift rate is more than 295m/Ma from 25.5Ma to 10.3Ma and more than 667 m/Ma from 6Ma up to now. The rapid uplift stage of Ganluo is earlyer than that of Mabian and Lincang, and significantly later than that of Western Panzhihua, this uplift feature is coincide with the outward propagation and growth deformation of tibetan plateau, which is is characterized by multistage coeval and disequilibrium developments. The results of tectonic subsidence history indicates the deep buried diagenesis after mineralization is significant for the preservation of Primary lead-zinc mine, and affects the current emplacement depth of ore body.