Plenty of Pb-Zn, Au polymetallic deposits developed in Liao-ji rift, and this study choose Zhenzigou Pb-Zn deposit in Qingchengzi, Baiyun Au deposit, Wulong Au deposit, Huanggoushan Pb-Zn deposit and Linjiang Au deposit as the objects of the research to analysis the sulfur, lead isotope and its geological significance. The results show that the δ34SCDT values of Zhenzigou veined Pb-Zn vary from -10.3‰～6.8‰, the δ34SCDT values of Baiyun Au deposit vary from -7.7‰～1.9‰, the δ34SCDT values of Wulong Au deposit vary from 0.8‰～3.6‰, the δ34SCDT values of Huanggoushan Pb-Zn deposit vary from 6.7‰～17.8‰, the δ34SCDT values of Linjiang Au deposit vary from 0.7‰～1.5‰. Two sulfur source exist in polymetallic deposit in Liao-ji rift: one of the type is formation sulfur and the other type is magmatic sulfur. Layered ore body of Zhenzigou Pb-Zn deposit belong to the first type, and the sulfur in veined Pb-Zn ore body, Baiyun Au deposit, Wulong Au deposit and Linjiang Au deposit belong to de later type. The formation sulfur aways contamined by the later magmatic sulfur. The Pb isotope from these deposits varied greatly. The 206Pb/204Pb, 207Pb/204Pb and 208Pb/204Pb range respectively within 15.32～16.43, 15.72～24.02 and 34.96～39.79, while every deposit had its own characters. The μvalue of ore lead isotope of the study objects are relative concentrated and high, show upper crust lead source and contamined by different other type lead isotope. Lead isotope of veined Pb-Zn ore body and rock body in Zhenzigou are mixed lead, while lead of veined ore body lead is mixed by upper crust lead and mantle lead, the lead of rock body is mixed by orogenic belt lead and upper crust lead. Ore lead of Baiyun Au deposit is orogenic belt lead, while rock body lead is mixed by upper crust lead and mantle lead. Lead isotope of Wulong Au deposit is mainly orogenic belt lead and contamined by mantle lead. Two lead types developed in Huanggoushan Pb-Zn deposit, one type is normal lead, which contain slightly more thorium and mainly from unite source bed. The other type is radiogenic lead (Uranium lead), and ore lead of Linjiang Au deposit belong to this type.