Abstract: The 373 uranium deposits, as a typical carbonanceous-siliceous-pelitic rock type uranium Deposits in South of China which has developed in a sequence including the weakly silicified black mudstone, silicified bioclastic limestone and the gradational rocks between them. The 373 uranium deposits is characterized with faults at which the uranium was mineralized widespread. Based on the geochemistry studies, it suggest that, (a) three episode veins has a distinct feature in trace element of geochemistry, with deficient of Ti, Sc, Cr, Cu, Zn elements and of Nb, Ta, Zr, Hf element, while it relatively enriched As, Sb, Mo, Tl and U elements. Furthermore, there are distinct features of hydrotherm effects in the deposits, the enriched Ba, Sb, As and Mo etc. elements are related with hydrotherm intrusion in three episode veins, (b) the enriched Co, Ni, Zn, As, Sb, Mo, Cd, W, Tl, Pb, Bi and U elements, in particular As, Sb, Mo, Tl and U elements, are with enrichment coefficients of ~100, and the correlation coefficient between the U element relative to W, As, Sb and Pb elements is ~0.9. All indicate relative homology of uranium mineralization, related to hydrothermal activity. (c)There is a positive relationship between concentration of trace elements and silicification in strata in our typical profiles. However, after the maximum of concentration of trace elements, the relationship becomes to be negative. (d)It is indicted that the uranium mineralization was deposited under an anoxic and deoxidated setting by the ratios of V/Cr, V/Sc, Ni/Co, V/(V+Ni), U/Th, δU, δEu and δCe, with much hydrothermal influence by the diagram of U-Th and graphic of Zn-Ni-Co, respectively.(e) characterization of trace element and characteristic element ratio reflect that carbonanceous-siliceous-pelitic rock formed in anoxic reducing environment which joined into hydrothermal fluid, Pre-enrichment of Uranium was related to the hydrothermal sediments,and Uranium mineralized was related to hydrothermal superimposed. Upward later hydrothermal fluid into reservoir bed through migrated channel,which react with Pre-enriched uranium bed and superimposed mineralization.