Xinlu basin located in southern margin of the Yangtze block of the north side of the middle Jiangshan-Shaoxing deep-fault is a volcanic faulted-basin developed in Yanshan epoch. It is an important integral part of GanHang volcanic-type uranium metallogenic belt. The purpose of the paper is to take a fresh insight on volcanic-type uranium mineralization in Xinlu Basin. Based on systematical studying to the dynamic geochemical trends of major-elements, trace-elements and Sr-Nd isotope during Mesozoic magmatic processes, Deep Geodynamics mechanism of volcanic-type uranium mineralization in Xinlu Basin were discussed by the paper. The results indicated that SiO2 contents is gradually lower, A.R., K2O/Na2O, LREE, δEu, Sr contents is gradually higher；The contents of Oxide is in “jumping” changing and trends to diabase, and changing of trace elements ratios is also in trendual；The evolution characteristics of Sr-Nd isotope is in mixed evolution trend line from Huangjian formation acidic volcanic rocks, granite-porphyry to diabase，Fruolite points symbolized isotopes of ore-forming fluids were projected on the mixed evolution trend line，and to be more approach to diabase area than granite-porphyry. Following ideas were concluded that：the ore-forming fluids sources of uranium ore-deposits in Xinlu basin is originated both from crust and enriched mantle；the genetic relationship between volcanic-type uranium mineralization and acidic volcanic rocks is symbiotic and coupling relationship in space that formed in different stages under mechanism of Mesozoic crust-mantle interaction；Continuous upwelling of the high temperature \"light material flow\" that come from lithosphere enriched mantle and its inducing effect plays an important role in controlling Mesozoic series acidic magmatic activity and uranium mineralization in Xinlu basin，acting both as sources of power and ore-forming fluids．