Using the passive-source seismic data collected during November 2009 to March 2011 in a multidisciplinary cross-section in the mid-lower Yangtze metallogenic belt, we conducted receiver function imaging etc., and obtained images with great clearance of the crust and upper mantle structures in the study region. First, the receiver function image shows the Moho depth varies significantly along the profile in the study region, and a “mantle uplift” is shown just beneath the Yangtze metallogenic belt (will refer to the Nanjing-Wuhu ore district of the Yangtze metallogenic belt in this paper if not stressed, the same below). In the southeast section of the northern margin of Yangtze craton, Moho topography is relatively stable with depths of about 30km, and in the vicinity of the Jiangnan fault and the Maoshan fault, Moho surface is shown rugged up, and to the centre part of the cross-section or beneath the Nanjing-Wuhu ore district, the Moho is shown uplift obviously with a depth of only about 28km, below the Tan-Lu fault zone the Moho is seen deepened up to a depth of 36km, and further north to the southern margin of North China block, Moho depth is shown gradually restored to depth of about 32km or to the level of the average depth. Secondly, we found in the results of receiver function image the lower crus of the Yangtze metallogenic belt is different from its surrounding in the structures, and the lower crust of the Yangtze metallogenic belt is significantly seismic azimuthal anisotropic. The lower crust beneath the northern margin of Yangtze craton is seen in a nearly horizontal structure with high velocity but without appearent seismic anisotropy; Contrastly, the lower crust beneath the Yangtze metallogenic belt is although in a nearly horizontal structure, but shown to be in high velocity for seismic waves propagated approximately along the strike of the metallogenic belt, and shown to be in low velocity for seismic waves propagated approximately normal to the strike, which means that the lower crust of the metallogenic belt exists belt-parallel seismic anisotropy. We interprete this phenomenon is due to the melting, flow and mineral crystal orientation in the lower crust. Finally, we observed a converted interface extened from the shallow crust to the middle and lower crust on the northern side of the TanLu fault in the southern margin of North China, which dips to southeast and interpreted to be related to the crustal extension within the Hefei Basin. In addition, we found that the \"mantle uplift structure\" observed in the receiver function result is in a good correspondence to a low velocity zone in the upper mantle at depths of about 150km beneath the metallogenic belt on the teleseismic P wave tomogram (Jiang Guoming et al., in another paper). We interpreted both of them to be a result of asthenosphere upwelling. Integrated the results from the seismic imaging of receiver function with the one from the teleseismic P wave tomography and previous research results in magmatic rocks and so on, we suggest that the formation of the Yangtze metallogenic belt to be a result MASH mineralization. First, the upwelling asthenosphere led to a extensional environment in the the Yangtze metallogenic belt and its surrounding regions, and resulted in a series of extensional structures in the middle to upper crust; then, upwelling asthenospheric materials underplated into the lower crust of the Yangtze metallogenic belt, and occurred assimilation when mixed with the lower crustal material in situ, resulted in the formation of adakitic-like magma; Then adakitic magma rised up along the extensional and the decollemental structures in the shallow crust as intrusive bodies, and reacted with country rock to form the mineral deposits.