Numerous mesozoic intermediate-acid intrusions are exposed in Tongling and adjacent area of the middle and lower reaches of the Yangtze River and they can be divided into five zones viz. Dabie zone, Luzong zone, Tongling outer zone, Tongling inner zone and Jiangnan zone, according to the high precision age date and geochemical characteristics of the rocks. Major element, trace element and rare earth element geochemistry from the rocks in the zones show that magmatism and magmatic evolvement mechanism for the intrusions are distinct differentiation. Stage of magmatic activity, zoning of the intrusions and different geochemistry characteristics of the rocks related to the deep-seated magmatism and its tectonic setting. The Mesozoic intrusions in Tongling inner zone formed in an extrusional regime, the intrusions in Tongling outer zone in an extensional regime, and those in Luzong zone formed during the course from extrusional to extensional regime. The Mesozoic intermediate-acid intrusions in the Tongling and adjacent area resulted from the process of the lithospheric thinning occurring in the eastern North China Block.