The Jiujiang-Ruichang area is an important metallogenic district which is located in the western section of the Cu-Fe-Au (S) mineralization belt of the Middle-Lower Reaches of the Yangtze River. In the present study we first present precise LA-ICP-MS zircon U–Pb dating for the samples from the Dingjiashan, Yangjishan, Baoshan, Tongling and Dalang bodies which are genetically associated with Cu-Au mineralization whereas there have been only a few studies on these bodies so far. Zircon U–Pb dating results indicate that these granitic bodies were formed in Late Jurassic to Early Cretaceous time at 145.4±1.2 Ma, 144.8±1.3 Ma, 143.6±1.2 Ma, 141.2±1.3 Ma and 146.4±1.2 Ma, respectively. On the other hand, these crystallization ages can be taken as close to the mineralization age. Through integration of the geological characteristics of the studied area, we suggest that the petrogenetic-metallogenic event in the Jiujiang-Ruichang metallogenic district probably occurred in a transitional environment from the early orogeny stage of the paleo-Pacific plate subduction to the subsequent back-arc extensional environment. However, it is still needed to further study whether they were formed by melting of overthickened or delaminated lower crust, or resulted from the ridge subduction along the lower Yangtze River area.