Due to high mountain conditions and high-dense covering of forests in south Anhui, the geological survey is difficult and geological exploration is relative weak . The breakthough of gold- prosepcting has not been achieved. This study focuses on the Tianjingshan gold deposit in south Anhui by means of geological survey, element analysis and statistics on geochemical database of sedimentary rocks, magmatic rocks and gold deposits around the deposit. The systematic statistics on major and trace elements has been done, discussing relationship between gold formation and geologic strata, magmatic rocks and regional structure in both Tianjingshan gold deposit and Jinshan ultra-scale gold deposit (Jiangxi Province). We established engineering in this deposit and obtained good ore bodies in Xiaohe gold distirct in the Tianjingshan gold mine, proving that this region is good for forming and prospecting large-scale gold deposit in south Anhui.