The study of Cenozoic deformation and uplift of the Tibetan Plateau is a hot issue of recent earth science. The Yumu Shan, located in the northeastern margin of the Qilian Shan, Northeast Tibetan Plateau, is the key point for deciphering the spatio-temporal evolution of the entire plateau. The thickness molasse (Yumen Conglomerate) deposited in the Yumu Shan region, with bottom age of ~3.58 Ma by the magneteostratigraphy. Basing on the paleocurrents, magnetic susceptibility, field research and published results, the Yumen Conglomerate should be dominated by tectonics since ~3.58 Ma than climate change. Three unconformities related to the Yumen Conglomerate span the intervals during ~5.23~3.58, ~2.88~2.58 and <~1.77~0.8Ma, respectively. So the deformation and uplift of the Yumu Shan is not later than 3.58 Ma, then successive tectonics occurred at lest two episodic uplift. This result did not support the northward growth model of the Tibetan Plateau, and this tectonic event should be the part response of Qingzang-Kunhuang Movement.