In east-central Tibet, Many Paleogene elongate basins with medium-mini-type are distributed along the large-scale arc-shaped strike-slip and thrust belt of the Nangqian-Yushu and Batang-Lijiang. Detailed mapping, structural-sedimentologic, biostratigraphic, geochemical, and 40Ar/39Ar chronologic data from five Pleogene basins (Dongba, Shanglaxiu, Nangqian, Gongjue, and Mangkang) in the Nangqian-Yushu and Batang region of east-central Tibet indicate that the strata in basin margin developed a large-scale of tilting to form high-steep dip and extrusing syncline, fold and deformation, filled amaranth clastics interbeded with volcanoclastic rock, carbonite and gypsum in basins, and incised by late magmatite. Pollen and paleoflora in fine-clastic rock, 40Ar/39Ar dating of volcanoclastic rock and magmatite show that the basin-filling sediments formed at 38-28Ma (Late Eocene-Early Oligocene). Paleogene amaranth sediments, carbonate and gypsum present a dry-fervent, evaporated paleoclimate environment. At the late Eocene to early Oligocene in Tibetan plateau（38-28Ma）, the break and closure of Paleogene basins of east-central Tibet may foreshow the start of wide early tectonic uplift and crust deformation due to the Indo-Asia collision.