On the basis of the seismic interpretation and the distribution of the Middle and Lower Cambrian halite layer, this paper mainly addresses the deformation features and mechanisms of the faults in the Tazhong uplift, central Tarim basin. On the seismic profiles, the faults have bigger dips on the upper parts, and detached on the top of the Middle and Lower Cambrian halite layer, or in the halite layer, with various detachment distances in different parts along the fault trends. In general, the faults in the study area express the typical features of salt-related faults. The development of faults in the Tazhong uplift were jointly influenced by the regional tectonic stresses, pre-existing basement faults and the halite layer of the Middle and Lower Cambrian. The regional stresses with varying orientations and sizes provided driving forces for the fault development, the thickness of the halite layer controlled the break behaviors of the halite and suprasalt strata, and the pre-existing basement faults decided the primary position of the faults.