Machangqing CuMoAu deposit is one of the deposits which have a close genetic relation with Himalayan alkaline intrusive in western Yunnan Province. The CuMoAu mineralization is spatially and temporally accompanied with the Machangqing intrusive. There are distinct zonations of alteration, mineralization and the element assemblages: porphyrytype CuMo mineralization inside the intrusive, contact metasomatictype CuMoAu mineralization along the contact between the intrusive and surrounding rock, epithermal AuAgPbZn mineralization in wallrock, and CuMo mineralization mainly in the alteration zone of quartzKfeldsparsericite of intrusive. The spatial and temporal relationship of metallogeny, the types of mineralization and alteration, and the distribution of element association display that oreforming fluid deriving from magma crystallization accumulated along the path while migrating outward. Isotopic geochemistry research shows that CuMoAu deposits may be the products of the same magmatictectonic metallogenic system under different physicalchemical conditions. Alkaline intrusive rock in Himalayan provided oreforming material and fluid, and the thermal dynamic condition for deposit formation, which is reflected by the alteration change from the interior of porphyry mass to contact zone and country rock. The types of mineralizatin, alteration of the country rock, as well as element assemblage indicate the evolution process from high temperature to low temperature suggesting an indispensable result of magmatic evolution.