Shuiyindong is one of the largest (more than 100 tonnes Au) and highest grade (more than 7 to 10 ppm), stratabound Carlin-type gold deposits in southwestern Guizhou Province, China. The deposit is controlled by both the structure and favorable lithology. It is situated near the axis of the striking Huijiabao anticline and is hosted in bioclastic limestone of the Permian Longtan Formation. Gold mineralization occurred under low-temperature with Th of 220℃± and is closely associated with decarbonation, silicification, sulfidation. The deposit has characteristic elemental assemblages of Au-As-Hg-Tl. Studies of geochemistry and isotope compositions indicate that the ore-bearing materials and fluids of the gold deposit mainly originated from plutonic source, and possess a mixing features with the strata matter during transportation from mantle to crust. Fluid inclusions in vein quartz from the gold deposit are rich volatile flux and indicating that metallogenic fluid is an overpressured one. The activity and heat-state of Earth’s crust in long period are favorable for the formation of overpressured fluids in a large area, and extensive structures drove the fluids into ore-forming system and made gold deposits formed. The complexity of structural movement in upper crust of southwestern Guizhou, resulted in a complicated gold mineralization. Through metallogenic pognosis and exploration, demonstrated reserves of the deposit increases tens of tones Au and the deposit become a superlarge stratabound Carlin-type gold deposit.