Anomalous hydrocarbon gases at the lower atmosphere and microbial germs in the subsurface sediment are found in the North Yellow Sea basin. In combination with the regional geological data and the proven oil-gas discoveries, the anomalies are indicative of three oil-gas prospects in the North Yellow Sea, which are located in the east, the middle and the west of the study area respectively. The middle oil-gas prospect, which is in the south of the N-S striking heave, is an area with a great potential, where methane concentrations at the lower atmosphere are homogeneously and continuously high in the plane with little variance and microbial germs in the subsurface sediment are of the strongest anomalies. The east oil-gas prospect is a relatively good potential area, where methane concentrations at the lower atmosphere ranges from middle to high levels and microbial germs in the subsurface sediment is of strong anomalies. The west oil-gas prospect is of little expectation for oil-gas because methane concentrations at the lower atmosphere are occasionally high in the plane and microbial germs of subsurface sediment are of relatively weak anomalies.