Both porphyry type and skarn type mineralization are developed in the Tongshankou Cu (Mo) deposit, southeastern Hubei Fe-Cu province. The genesis of the deposit is related to the Tongshankou granodiorite porphyry and the Lower Triassic Daye Group carbonates, and orebodies are primarily hosted in their contact region. This paper presents precise 40Ar/39Ar ages of alteration sericites and phlogopite related to the porphyry type and skarn type mineralization, respectively, obtained by laser incremental 40Ar/39Ar analysis. Our results suggest that the Tongshankou ore deposit and the granodiorite host formed at ca. 143 Ma; whereas the Niubifeng quartz monzonite occurred to the southeast of the mining area was emplaced at ca. 129 Ma. 40Ar/ 39Ar geochronometer of the Tongshankou deposit has been partially resetted by the later-stage magmatism. When combined with previous results, this study suggests that there are two phases of magmatism and its related mineralization in southeastern Hubei and other metallogenic regions along the middle-lower Yangtze River occurred at 145-133 Ma and 130-120 Ma, respectively. Magma underplating and subsequent lithospheric extension could have been the geodynamic setting responsible for the voluminous magmatism and large-scale mineralization.