The Tuwu and Yandong large porphyry copper (molybdenum) deposits were discovered recently in south-eastern Xinjiang, form the Eastern Tianshan porphyry copper belt. As shown by the chronological constraints, the age of plagiogranite porphyry related to mineralizaiton is about 369 ~ 356 Ma (Rb-Sr isochron dating and single-grain zircon U-Pb dating) , the age of molybdenite is 320 Ma (Re-Os isochron dating) , and the age of al-tered rocks is about 341-310 Ma. The ore-bearing wall-rocks, trachybasalt and trachyandesite probably oc-curred in the Devonian (Sm-Nb age, 416 Ma; single-grain zircon U-Pb ages, 356 Ma, 390 Ma and 440 Ma). The porphyry copper deposits are the product of island-arc volcanism-plutonism. To the south of the porphyry copper belt is the well-known Kanggurtag gold belt, and further south is the Xingxingxia silver belt. Therefor-e, from north to south, the assemblage of the erogenic deposits is manifested as the porphyry copper (molybde-num) belt-ductile shear and epithermal gold belt-epithermal (tectonic alteration) silver belt. The instrusion ages are older in the north than those in the south. All the evidence indicates that the partial melting depths of granitic magma became deeper southwards, and implies that the tectonomagmatic plane was subducted from north to south. As the reflection of the crust-mantle evolution, tectonomagmatism in the Eastern Tianshan persisted from 370 to 240 Ma, which implies that there seemed to be a belt of continuous evolution of granitic magma from Haerlike and Kanggurtag in the north to the Central Tianshan in the south. No sign is found that plutonism has been interrupted by several extension events that occurred in the Eastern Tianshan during the Pa-leozoic.The authors discusses the mineralization mechanisms and tectonic framework of porphyry copper deposits, gold deposits of ductile shear belt type and silver deposits of tectonic alteration type in the Eastern Tianshan and construct a mineralization model, which suggests the new direction in mineral prospecting in the Eastern Tian-shan orogen.